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. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Nat Biomed Eng. 2021 Apr 15;5(4):360–376. doi: 10.1038/s41551-021-00703-2

Fig. 6 |. A plausible regulatory relationship between UHRF1 and 34 in-frame translocation genes identified in ETV6-RUNX1 ALL.

Fig. 6 |

An information-theoretic analysis of single-cell RNA sequencing data identifies a network relationship between UHRF1 and 34 translocation genes driving significant and targeted expression discordance of genetic drivers in ALL. In this network, UHRF1 may play the most influential role as compared to other genes in the network. Red, overexpression; brown, upregulated expression variance; blue, no change in expression variance.