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. Author manuscript; available in PMC: 2022 Jun 18.
Published in final edited form as: Science. 2021 Jun 18;372(6548):eabf3736. doi: 10.1126/science.abf3736

Fig. 4. Selected pairwise genetic correlations between DTI parameters of white matter tracts and brain disorders and cognitive functions.

Fig. 4

(A) The asterisks (for FA PCs) and daggers (for mean parameters) highlight significant genetic correlations after controlling the FDR at 5% level. The y-axis lists the DTI parameters of white matter tracts and the x-axis provides the names of brain-related traits/disorders. The colors represent genetic correlations (gc). FA, fractional anisotropy; AD, axial diffusivity; MD, mean diffusivity; MO, mode of anisotropy; RD, radial diffusivity; PC, principal component of FA; ALS, amyotrophic lateral sclerosis; ASD, autism spectrum disorder; MDD, major depressive disorder; SCZ, schizophrenia; ADHD, attention-deficit/hyperactivity disorder. (B-E) Location of the white matter tracts whose DTI parameters were genetically correlated with (B) stroke (any subtype); (C) MDD; (D) intelligence; and (E) reaction time. The colors describe different white matter tracts.