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. 2021 Sep;27(9):1004–1016. doi: 10.1261/rna.078709.121

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© 2021 Johnson et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 1. — Effect of loss of TNRC6A, TNRC6B, or TNRC6C expression on cell cycle and cell proliferation. (A) Diagram of TNRC6A, TNRC6B, and TNRC6C proteins, with known motifs, knockout mutations, and deletions. (B) Bar graph of TNRC6 paralog's fragments per kilobase values obtained from whole-cell RNA sequencing of knockout cell lines. TNRC6B and FAM83F are overlapping genes. (C) Percentage of cells in each stage of the cell cycle. (D) Growth curve for cell lines transfected with anti-TNRC6C siRNA. (E) Percentage of cells in each stage of the cell cycle for transfected cell lines wild-type after transfection with siTNRC6C, or control duplex siGL2. (*) P > 0.05; (**) P > 0.01. (***) P > 0.001.