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. 2021 Sep;27(9):1004–1016. doi: 10.1261/rna.078709.121

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© 2021 Johnson et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 4. — Comparison of gene expression in TNRC6 and AGO knockout cells. (A) Heatmap of Log₂FoldChange gene expression changes of 95 genes with AGO2 protein binding clusters that change significantly only in the TNRC6AB^−/− siTNRC6C cells. (B) Heatmap of Log₂FoldChange gene expression changes of 252 genes with AGO2 clusters that change significantly in TNRC6 AB^−/− siTNRC6C and AGO123^−/− cells (not including the 67 genes previously shown in Fig. 3B). (C) Correlation plot of the 95 genes unique to TNRC6 AB^−/− siC shown in A of AGO 123^−/− and TNRC6 AB^−/− siC log2FoldChanges. Shaded region is 95% confidence band. (D) Correlation plot of the 252 genes changed in AGO123^−/− and TNRC6 AB^−/− siC in shown in B of AGO 123^−/− and TNRC6 AB^−/− siC log₂FoldChanges. Shaded region is 95% confidence band.