Table 3.
Subgroup Analysis of the Associations Between 30-Day All-Cause Mortality and the SII
| Subgroups | N | SII | P for Interaction | ||
|---|---|---|---|---|---|
| <75.5 | 75.6−104.2 | >104.2 | |||
| AKI | 0.6079 | ||||
| No | 119 | 1.0 | 0.45 (0.04, 4.49) 0.4943 | 2.16 (0.45, 10.35) 0.3351 | |
| Yes | 412 | 1.0 | 1.37 (0.67, 2.79) 0.3879 | 2.69 (1.38, 5.25) 0.0038 | |
| Sepsis | 0.0685 | ||||
| No | 404 | 1.0 | 2.53 (1.02, 6.27) 0.0449 | 4.26 (1.77, 10.24) 0.0012 | |
| Yes | 127 | 1.0 | 0.48 (0.16, 1.48) 0.2020 | 1.54 (0.60, 3.90) 0.3679 | |
| CHF | 0.6062 | ||||
| No | 479 | 1.0 | 1.45 (0.71, 2.96) 0.3090 | 3.07 (1.58, 5.96) 0.0009 | |
| Yes | 52 | 1.0 | 0.71 (0.12, 4.30) 0.7132 | 1.25 (0.25, 6.16) 0.7840 | |
| Chronic renal disease | 0.5527 | ||||
| No | 480 | 1.0 | 1.50 (0.75, 3.01) 0.2553 | 2.97 (1.56, 5.66) 0.0009 | |
| Yes | 51 | 1.0 | 0.43 (0.05, 3.53) 0.4312 | 1.38 (0.21, 9.24) 0.7369 | |
| Chronic live disease | 0.6067 | ||||
| No | 468 | 1.0 | 1.31 (0.65, 2.63) 0.4558 | 2.24 (1.14, 4.39) 0.0192 | |
| Yes | 63 | 1.0 | 1.62 (0.23, 11.46) 0.6262 | 4.79 (0.93, 24.72) 0.0614 | |
| CAD | 0.8467 | ||||
| No | 460 | 1.0 | 1.38 (0.66, 2.86) 0.3901 | 2.75 (1.41, 5.37) 0.0030 | |
| Yes | 71 | 1.0 | 0.96 (0.20, 4.60) 0.9609 | 2.86 (0.63, 12.98) 0.1740 | |
| Hypertension | 0.5009 | ||||
| No | 253 | 1.0 | 1.81 (0.62, 5.23) 0.2747 | 4.21 (1.61, 11.01) 0.0033 | |
| Yes | 278 | 1.0 | 1.06 (0.45, 2.47) 0.8917 | 2.01 (0.90, 4.49) 0.0905 | |
| Pneumonia | 0.9155 | ||||
| No | 388 | 1.0 | 1.47 (0.66, 3.27) 0.3487 | 2.92 (1.39, 6.15) 0.0047 | |
| Yes | 143 | 1.0 | 1.09 (0.34, 3.51) 0.8912 | 2.55 (0.87, 7.43) 0.0865 | |
| DM | 0.7598 | ||||
| No | 408 | 1.0 | 1.48 (0.68, 3.23) 0.3274 | 2.82 (1.38, 5.75) 0.0045 | |
| Yes | 123 | 1.0 | 0.96 (0.28, 3.32) 0.9542 | 2.84 (0.87, 9.28) 0.0838 | |
| Depression | 0.5293 | ||||
| No | 475 | 1.0 | 1.51 (0.75, 3.05) 0.2532 | 3.03 (1.57, 5.87) 0.0010 | |
| Yes | 56 | 1.0 | 0.40 (0.04, 4.26) 0.4476 | 1.60 (0.31, 8.30) 0.5758 | |
| Alcohol abuse | 0.9511 | ||||
| No | 396 | 1.0 | 1.27 (0.60, 2.69) 0.5369 | 2.72 (1.38, 5.38) 0.0040 | |
| Yes | 135 | 1.0 | 1.64 (0.39, 6.80) 0.4968 | 3.14 (0.79, 12.43) 0.1026 | |
| SOFA group | 0.6802 | ||||
| ≤4 | 233 | 1.0 | 6.38 (0.75, 54.18) 0.0895 | 10.50 (1.26, 87.69) 0.0299 | |
| >4 | 298 | 1.0 | 0.93 (0.44, 1.97) 0.8553 | 1.88 (0.96, 3.70) 0.0659 | |
| APS III group | 0.6178 | ||||
| ≤48 | 261 | 1.0 | 2.16 (0.52, 8.90) 0.2867 | 4.15 (1.06, 16.27) 0.0410 | |
| >48 | 270 | 1.0 | 1.00 (0.46, 2.19) 0.9922 | 1.87 (0.92, 3.81) 0.0846 | |
Notes: Confounders adjustment were performed as in Model 1 (Table 2). Cox proportional hazards regression models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs).