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Immunization groups.
| Group | TLR Ligand | Target Receptor | Group Name | VLP dose (μg) | Adjuvant Dose (μg) | Adjuvant Concentration (μM) | Adjuvant Concentration (nmol/dose) |
|---|---|---|---|---|---|---|---|
| 1 | PBS | ||||||
| 2 | VLPs | 200 | |||||
| 3 | CALV + VLPs | 200 | |||||
| 4 | PAM3CAG | TLR2 | CALV(PAM3CAG) + VLPs | 200 | 100 | 500 | 25 |
| 5 | dsRNA | TLR3 | CALV(dsRNA) + VLPs | 200 | 100 | 1 | 0.05 |
| 6 | MPLA | TLR4 | CALV(MPLA) + VLPs | 200 | 25 | 300 | 15 |
| 7 | resiquimod (R848) | TLR7/8 | CALV(R848) + VLPs | 200 | 100 | 6000 | 300 |
