Table 7.
Validation of the novel PCNSL LLR scoring system.
| Model | Patient, n | Median OS | 5-Year OS rates | HR (95%CI) | P value |
|---|---|---|---|---|---|
| MSKCC score | 0.008 | ||||
| Low-risk | 16 (19%) | 44 | 33.3% | – | |
| Intermediate-risk | 49 (58%) | 48 | 40.9% | 1.913 (0.665,5.503) | |
| High-risk | 19 (23%) | 18 | 11.6% | 4.521 (1.476,13.848) | |
| PCNSL LLR score | 0.005 | ||||
| Low-risk | 33 (39%) | 74 | 61.9% | – | |
| Intermediate-risk | 32 (38%) | 32 | 30.2% | 1.920 (0.898,4.108) | |
| High-risk | 19 (23%) | 18 | 11.6% | 3.899 (1.712,8.882) |
MSKCC, Memorial Sloan Kettering Cancer Center; OS, overall survival; the median overall survival time is calculated in months; HR, hazard ratio; CI, confidence interval; low-risk (age <50 or KPS ≥70, and LLR ≤ 166.8), intermediate-risk (age <50 or KPS ≥70, and LLR > 166.8) and high-risk (age ≥50 and KPS <70).