Table 2.

Estimated evidence profile and appraisal of the strength of the recommendation regarding the adjunctive effect of locally delivered antibiotics during periodontal surgery on clinical attachment level gain (>6 to 12 months; primary outcome)

GRADE criteria	Rating
Risk of bias	Serious concern
Inconsistency	Serious concern
Indirectness	No (clinical outcome)
Imprecision	Yes
Publication bias	No clear bias
Other considerations for upgrading the overall rating (magnitude of the effect, dose-dependent relationship, confounders)	No
Strength of the recommendation based on the quality and body of evidence	Very low