Figure 1.

Body weight, CatWalk gait analysis and rotarod performance. (A) Male neuroscores. (B) Female neuroscores. (C) Male body weight. (D) Female body weight. (E) Male rotarod performance. (F) Female rotarod performance. (G) Male rotarod performance/weight. (H) Female rotarod performance/weight. Error bars represent mean ± SD. All graphs contain data for TDP-43^Q331K (n = 6 per gender—depicted by the blue lines), TDP-43^WT (n = 6 per gender—depicted by the green lines) and non-transgenic (n = 12 per gender—depicted by the red lines) mice compared using a two-way ANOVA with Tukey’s post-tests. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 TDP-43^Q331K vs all other groups.