Figure 2.

CatWalk gait analysis showing paw print patterns; walking duration, hindlimb base of support and diagonal pattern walking in TDP-43^Q331K mice compared to TDP-43^WT and non-transgenic mice. Footprint traces of non-transgenic (A), TDP-43^WT (B) and TDP-43^Q331K (C) mice at 10 months of age. Red prints = right limbs, green prints = left limbs, bright prints = forelimbs, darker prints = hindlimbs. In TDP-43^Q331K n = 6 males, 6 females, NTg n = 12 males, 12 females, TDP-43^WT n = 6 males, 6 females. Analysis of individual gait parameters over time in the TDP-43^Q331K, TDP-43^WT and non-transgenic mice. Mean (± SD) walking duration (time to walk a distance of 43.8 cm) in seconds was measured in males (D) and females (E). Mean (± SD) hindlimb base of support (distance between hind paws) was measured in males (F) and females (G). Mean (± SD) diagonal stepping pattern in males (H) and females (I). *p < 0.05 vs all other groups, **p < 0.01 vs all other groups, ***p < 0.001 vs all other groups, ****p < 0.0001 vs all other groups, two way ANOVA with Tukey's post-tests.