Figure 5.

Muscle weights and electrophysiology. (A) Mean (± SD) gastrocnemius/soleus muscle weights of female mice at 10 months of age TDP-43^Q331K n = 10, NTg n = 12, TDP-43^WT n = 6. (B) Compound muscle action potential (CMAP) of the lower hindlimb of TDP-43^Q331K mice and non-transgenic mice (± SD) at 9–11 months of age (n = 3). ***p < 0.001 vs all other groups, ****p < 0.0001 vs other groups, one way ANOVA with Tukey's post-tests. (C, D) Fasciculation potentials recorded in two out of eight TDP-43^Q331K mice tested. Such electrophysiological activity was not seen in TDP-43^WT mice. Mice were tested for CMAP and fasciculation at the same time point.