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. 2021 Aug 4;12:643282. doi: 10.3389/fimmu.2021.643282

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Copyright © 2021 Pan, Zhang, Chen, Liu, Cao, Chen, Chen and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subgroup Analysis of Overall Survival in the MSKCC ICI cohort stratified by TMB. (A) Kaplan–Meier curves of overall survival in patients with BC by TMB. The median overall survival was 15.0 months (95% CI: 10.6–19.4 months) in the low-TMB group and not reached in the high-TMB group. (B) Kaplan–Meier curves of overall survival in patients from the high-TMB group. The median overall survival was 11.5 months (95% CI: 1.4–20.6 months) and not reached in the other two groups. (C) Kaplan–Meier curves of overall survival in patients from the low-TMB group. The median overall survival was 27.0 months (95% CI: not available) in the low-risk group, 11.0 months (95% CI: 7.5–14.5 months) in the moderate-risk group, and 7.0 months (95% CI: 10.6–19.4 months) in the high-risk group. BC, bladder cancer; CI, confidence interval; TMB, tumor mutation burden.