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. 2021 Aug 17;11:16696. doi: 10.1038/s41598-021-96274-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PPI network construction and hub gene identification. The PPI network consisted of 91 nodes and 304 edges. The red nodes indicate the upregulated genes, and the blue nodes indicate the downregulated DEGs. The node size represents the connectivity degree. The edge thickness represents the combined score. The network was visualized with Cytoscape software (Version 3.72, http://www.cytoscape.org/).