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. 2021 Aug 17;11:16691. doi: 10.1038/s41598-021-96300-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Remission odds and gene expression profiling of remission signature genes in CD8⁺ T cells. (A) Remission odds generated by the RA remission model. ‘*’: p < 0.05, ‘**’: p < 0.01, ‘***’: p < 0.001, ‘****’: p < 0.0001. (B) and (C) Primary component analysis using remission signature genes in the derivation cohort (B) and the validation cohort (C). The ellipse shows the 95% confidence interval of the value of principal component analysis. Patients in the validation cohort were treated by TCZ for 6 months and achieved remission after treatment. HC, healthy control; IFX, infliximab; MTX, methotrexate; RA, rheumatoid arthritis; NT, non-treatment; SF, synovial fluid; TCM, central memory T cell; TCZ, tocilizumab; TEM, effector memory T cell; TEMRA, CD45RA-positive effector memory T cell; TN, naïve T cell.