Table 2.
Spearman’s rho correlation and multivariate linear regression analyses determining associations between circulating COMP levels and clinical parameters in BA patients.
| Variables | Circulating COMP levels (ng/mL) | |||
|---|---|---|---|---|
| Spearman’s rho correlation | Linear regressiona | |||
| Coefficient (r) | P-value | β coefficient (95% CI) | P-value | |
| Age (years) | − 0.20 | 0.08 | – | – |
| BMI (kg/m2) | 0.12 | 0.38 | – | – |
| Liver stiffness (kPa) | 0.54 | < 0.001* | 0.33 (0.13 to 0.52) | 0.002* |
| AST (IU/L) | 0.47 | < 0.001* | – | – |
| ALT (IU/L) | 0.35 | < 0.001* | – | – |
| ALP (IU/L) | 0.32 | 0.002* | – | – |
| Albumin (g/dL) | − 0.23 | 0.047* | – | – |
| TB (mg/dL) | 0.44 | < 0.001* | – | – |
| DB (mg/dL) | 0.41 | < 0.001* | – | – |
ALP alkaline phosphatase, ALT alanine aminotransferase, APRI AST to platelet ratio index, AST aspartate aminotransferase, BA biliary atresia, BMI body mass index, DB direct bilirubin, TB total bilirubin, NA not available.
*Correlation is considered statistically significant at P-value less than 0.05 (two-tailed).
aThe coefficient was adjusted for age, BMI, AST, ALT, ALP, albumin, TB, and DB.