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. 2021 Aug 17;11:16666. doi: 10.1038/s41598-021-96150-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes in the retina after hypoxic exposure. (a) Number of differentially expressed genes identified for each hypoxic condition. Shown are genes with an FDR ≤ 0.05 (grey bars) and genes that were additionally filtered for an FC ≥ ± 2 (white bars) compared to normoxic controls. Nomenclature of groups is defined according to Table 1. (b) Volcano plot representing differentially expressed genes in the 7% acute normobaric hypoxia (07-06 h-ZH) group. Up-regulated genes are shown in red and down-regulated genes in blue. Plot shows − log₁₀ FDR versus log₂ FC of each gene detected in acute hypoxia relative to normoxia (N). Threshold limit lines are set at an FDR of 0.05 and log₂FC of ± 1. (c) Gene set enrichment analysis (GSEA) of 07-06 h-ZH (n = 6) compared with normoxia (n = 6) with MSigDB hallmark datasets. Heatmaps represent the top 10 upregulated genes in hypoxia for each hallmark set. Co-expression networks of top 30 enriched genes of each set. Nomenclature: ‘Oxygen percentage—duration of hypoxia—location of experiment’ is given in the name of each experimental group. ZH denotes normobaric and JFJ hypobaric hypoxic groups. N: normoxia; FC: fold change; FDRq: false discovery rate; NES: normalized enrichment score.