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. 2021 Aug 17;11:16666. doi: 10.1038/s41598-021-96150-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes after exposure to normobaric or hypobaric hypoxia. Volcano plots representing up-regulated (red) and down-regulated (blue) genes comparing (a) acute exposure (14-48 h-JFJ to 14-48 h-ZH) and (b) prolonged exposure (14-07w-JFJ to 14-11w-ZH) to hypobaric and normobaric hypoxia. Threshold limit lines are set at FDR of 0.05 and log₂FC of ± 1. (c) Venn diagram showing differentially regulated genes at each time-point and their overlap (grey). (d) Heatmap of the 17 shared genes identified in (c). Shown are up- (red) and down- (blue) regulated genes as log₂ fold change (FC) over normoxia in the short- or long-term groups as indicated.