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. 2021 Aug 17;11:16666. doi: 10.1038/s41598-021-96150-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes in the RPE. Expression of genes related to the hypoxic response (Hif1α, Epas1, Slc2a1, and Adm), glycolysis (Pdk1, Hk2), vascular perfusion (Vegfa, Angpt2), and choroidal connective tissue (Col1a1) was tested in eyecups by semiquantitative real-time PCR for all hypoxic conditions, as indicated. Expression levels were normalized to Actb and are shown relative to normoxic controls, which were set to 1 (dotted line). Shown are means ± SD of n = 6. Outliers detected by Grubb’s test (α = 0.01) are indicated as black dots and were excluded from statistical analysis. Significant differences of each condition to control (normoxia) was tested by one-way ANOVA with Dunnett’s multiple comparison test *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.