Skip to main content
. 2021 Aug 17;12:4977. doi: 10.1038/s41467-021-25246-7

Fig. 5. Identification of macrophage subsets in the synovium of patients with RA.

Fig. 5

a UMAP visualization of macrophages from the synovium. Among 46,973 cells, we identified 11 macrophage subtypes. Cells are marked by ACPA type(left) and cell subtypes (right). b Violin plots showing marker genes across cell subtypes in A. The y axis represents log-scaled normalized counts. c Left: Bar plots showing the relative percentage of STMC macrophage subtypes for each sample as in a. Right: Box plots showing the proportions of each STMC macrophage subtypes across ACPA groups. Cell types showed enrichment in ACPA+ or ACPA- subgroups are marked with *P values were calculated by the two-sided Wilcoxon test. *p < 0.05 (from left to right, p = 0.021, 0.043), **p < 0.01 (p = 0.0093). n = 10 for ACPA+ group, and n = 10 for ACPA- group. d Violin plots showing the differences in the expression of IL1B, TGFB1, and CD36 between ACPA- and ACPA+ macrophage subtypes in STMC. Asterisks indicate the significance. P values were calculated by the two-sided Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001.