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During viral infection, IFITM3 decreases proteolysis of virus capsid proteins, and restricts fusion and entry into the cytosol. During Lm infection, IFITM3-mediated suppression of proteolysis leads to increased LLO and ActA in the phagosome. After entering the cytosol, increased actin recruitment subsequently leads to an increase in cell-to-cell spread. Arrows indicate decrease (red) or increase (green) by IFITM3.
