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. 2021 Aug 17;11:16688. doi: 10.1038/s41598-021-96191-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamics of alkaline phosphatase in blood (A) and tissue (B) during and after three physical activities. simulated for 36 h/1.5 days (main) and 120 h/5 days (snippet). Marathon induces the highest level of alkaline phosphatase in tissue, followed by construction work and walking. Alkaline phosphatase is known to neutralise inflammation, hence, the more intense the inflammation is, the stronger it is induced.