Figure 9.

Dynamics of alkaline phosphatase in blood (main) and tissue (inset) for a temperature-dependent human innate immune system. At high initial levels of ITMs (A), all temperatures trigger the diffusion of AP from the bloodstream into the tissue. For healthy individuals with low initial ITMs (C), AP in the bloodstream is less used by the body, as evident from the subtle dips in AP concentrations. For intermediate initial ITMs (B) represented by individuals belonging to disadvantaged groups, results show slightly more consumption of AP for low core temperatures as compared to healthy individuals.