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. 2021 Aug 4;12:693333. doi: 10.3389/fneur.2021.693333
CSA quantification Recommendation Alternative
Which MRI acquisition? Dedicated cervical cord MRI incl. isotropic 3D T1w
Pro: best CSA repeatability
Con: long duration of brain and cervical cord MRI
brain MRI incl. sagittal 3D T1w to cover the upper cervical cord
Pro: Patient comfort/shorter MRI duration; only minor loss of CSA repeatability in brain MRI at C1–C2
Con: limited to upper cervical cord levels
Which vertebral level? Entire cervical cord (C1–C7)
Pro: best CSA repeatability
Con: averaging of regional changes
Regional cervical cord sections (e.g., C1–C2)
Con: repeatability of CSA slightly reduced