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. 2021 Feb 14;246(11):1330–1341. doi: 10.1177/1535370221993052

Figure 2.

Figure 2.

Progressive motor dysfunction and decreased β-galactosidase activity in KI/KI mice. (a) On the forelimb grip strength test, KI/KI mice (black bars) showed impaired strength of the forelimbs compared to wild type (WT) mice (white bars) and KI/+ mice (gray bars) (n = 4–11). (b) On the rotarod test of motor coordination and balance, the performance of KI/KI mice declined over time (n = 4–8). Results are expressed as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001. (c) The β-gal activity of DBS had decreased significantly in KI/KI mice (n = 24). (d) Significant deficiency of β-gal activity was observed in KI/KI mouse brain, heart, liver, and spleen tissues (n = 4). Results are expressed as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001. (e) qPCR analysis of Glb1 genes of WT, KI/+ and KI/KI mice (n = 3). The values are expressed as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001.