Figure 1.

Schematic representation of the NADome. Schematic representation of the network of substrates/ligands, NAD-metabolizing cell surface and intracellular enzymes and their products in the extracellular and intracellular space. Biological functions regulated by NAD-related enzymes and products are listed. NAD, nicotinamide adenine dinucleotide; NADP, NAD phosphate; eNAD, extracellular NAD; Nam, nicotinamide; NR, nicotinamide riboside; Na, nicotinic acid; NAMPT, nicotinamide phosphoribosyltransferase; NAPRT, nicotinate phosphoribosyltransferase; NRK, nicotinamide riboside kinase; ARTs, mono adenosine diphosphate (ADP)-ribose transferases; PARPs, poly ADP-ribose polymerases; ADPR, ADP ribose; cADPR, cyclic ADP ribose; NAADP, nicotinic acid adenine dinucleotide phosphate; Ca²⁺, calcium; NMN, nicotinamide mononucleotide; ADO, adenosine; AMP, adenosine monophosphate; ENPP1; ectonucleotide pyrophosphatase/phosphodiesterases; TLR4, toll-like receptor 4.