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. 2021 Aug 4;9:700854. doi: 10.3389/fcell.2021.700854

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Copyright © 2021 Fei, Xiang, Luo, Tan, Gu, Liu, Chen, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The function of CTRP1 on apoptosis and PERK signal pathway was inhibited by CCT020312. (A) Apoptosis was analyzed by TUNEL, n = 3 per group. The representative images were acquired under × 200 magnification, scale bars = 100 μm. (B) Western blot analyzed the expression CTRP1, BAX, CHOP, GRP78, ATF4, p-PERK, PERK, p-eIF2α, and eIF2α in the cortex. n = 6 per group. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05 vs. sham group, ^####p < 0.0001, ^##p < 0.01, ^#p < 0.05 vs. MCAO/R + LV-NC group, ^@@p < 0.01, ^@p < 0.05 vs. MCAO/R + LV-CTRP1 group.