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. 2021 Aug 4;9:700854. doi: 10.3389/fcell.2021.700854

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Copyright © 2021 Fei, Xiang, Luo, Tan, Gu, Liu, Chen, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCT020312 reversed the effect of CTRP1 on apoptosis and the PERK signal pathway after OGD/R. (A) MTT analyzed the cell viability in neurons. n = 4 per group. (B) TUNEL analyzed apoptosis in neurons. n = 3 per group. The representative images were acquired under × 200 magnification, scale bars = 100 μm. (C) The expression of CTRP1, BAX, Bcl-2, Cleaved caspase 3, Caspase 12 was analyzed by Western blot. n = 4 per group. (D) The relative expression of CHOP, GRP78, ATF4, PERK and p-PERK in neurons. n = 4 per group. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05 vs. control group, ^####p < 0.0001, ^###p < 0.001, ^##p < 0.01, ^#p < 0.05 vs. OGD/R + LV-NC group, ^@@@@p < 0.0001, ^@@ p < 0.01, ^@ p < 0.05 vs. OGD/R + LV-CTRP1 group.