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. 2021 Aug 4;11:683464. doi: 10.3389/fcimb.2021.683464

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Copyright © 2021 Rahmoun, Azrad and Peretz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of Metronidazole MIC values of non-biofilm producers, weak-, moderate- and strong biofilm-producing C. difficile isolates. The minimal, maximal and average MIC values are shown (the average is indicated by the line within the bar) for each group of isolates (non-producers, weak-, moderate- and strong producers’ groups). The mean metronidazole MIC of strong biofilm-producing isolates (n = 29) were significantly higher compared to MIC values of isolates that were non-producers (n = 57), weak producers (n = 14) and moderate producers (n = 23), ***p < 0.001. The p value represents the comparison of the mean MIC between the four categories of biofilm production capacity (ANOVA analysis).