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LncRNA mechanisms of action. (A) LncRNAs can act as a sponge to titrate miRNAs away from their mRNA targets. (B) The lncRNAs can act as miRNA precursors. (C) LncRNA can bind to transcription factors or other proteins as a decoy and sequester them away from chromatin (lower-right). (D) LncRNA can also serve as a scaffold to promote the assembling of chromatin remodeling complexes. (E) LncRNA can guide transcription factors to specific genomic locations for regulating gene expression.
