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. 2021 Aug 4;12:729745. doi: 10.3389/fphar.2021.729745

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Copyright © 2021 Huang, Peng, Jiang, Hu and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNAs are involved in the three major diseases, including atherosclerosis, NAFLD, and myocardial infarction (MI) caused by abnormal cholesterol levels and various lipid fractions. Various lncRNAs and their mechanisms are illustrated. APF: autophagy promoting factor; CAIF: cardiac autophagy inhibitory factor; CALM2: calmodulin 2; GSA5: growth arrest-specific transcript 5; lncRNA XIST: long non-coding RNA X-inactive specific transcript; NLRC5: nucleotide-binding and oligomerization domain-like receptor C5; Sfrp2: secreted frizzled-related protein 2.