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. 2021 Aug 4;8:696578. doi: 10.3389/fcvm.2021.696578

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Copyright © 2021 Zhang, Zhou, Yuan, Nan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) expression increased in hypoxia-treated endothelial cells in vitro and mouse ischemic hindlimb in vivo. (A) Prediction of an endothelial-specific expression of GABBR2 by RNA-seq data. (B) Re-speculation of the role of GABBR2 in angiogenesis. (C,D) Expression changes of GABBR2 in human umbilical vein endothelial cells (HUVECs) after hypoxia treatment for 1, 3, and 6 h. (E,F) Expression changes of GABBR2 in the muscle of mouse ischemic hindlimb on days 1, 3, and 7. *p <0.05; **p <0.01.