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. 2021 Aug 4;8:696578. doi: 10.3389/fcvm.2021.696578

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Copyright © 2021 Zhang, Zhou, Yuan, Nan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) knockdown on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs). (A) Downregulation of GABBR2 in HUVECs by lentivirus transfection. (B) Cellular proliferation changes induced by 6 h of hypoxic treatment in normal and GABBR2-downregulated HUVECs. (C) EdU staining induced by 6 h of hypoxic treatment in normal and GABBR2-downregulated HUVECs. (D) Wound healing distance changes induced by 6 h of hypoxic treatment in normal and GABBR2-downregulated HUVECs. (E) Tube-like construction formation induced by 6 h of hypoxic treatment in normal and GABBR2 downregulated HUVECs. *p < 0.05; **p < 0.01; ****p < 0.0001.