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. 2021 Aug 4;8:696578. doi: 10.3389/fcvm.2021.696578

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Copyright © 2021 Zhang, Zhou, Yuan, Nan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) knockdown on endothelial progenitor cell (EPC) mobilization in peripheral blood in hindlimb post-ischemia. (A) Representative images of CD34⁺/CD133⁺ cells in the peripheral blood of mice analyzed by flow cytometry. WT, normal mice; KD, GABBR2-downregulated mice; WT-H, wild-type (WT) mice with hindlimb ischemia; KD-H, GABBR2 knockdown (KD) mice with hindlimb ischemia. (B) Ratio of CD34⁺ cells in the peripheral blood of normal and ischemic mice. (C) Ratio of CD133⁺ cells in the peripheral blood of normal and ischemic mice. (D) Ratio of CD34⁺ and CD133⁺ cells in the peripheral blood of normal and ischemic mice. *p < 0.05; ***p < 0.001; ****p < 0.0001.