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. 2021 Aug 4;8:696578. doi: 10.3389/fcvm.2021.696578

Figure 5.

Figure 5

Effect of gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) knockdown on the glycolysis capacity of human umbilical vein endothelial cells (HUVECs) after hypoxia treatment. (A) Extracellular acidification rate (ECAR) changes induced by 6 h of hypoxic treatment in normal and GABBR2-downregulated HUVECs. WT, normal mice; KD, GABBR2-downregulated mice; WT-H, wild-type (WT) mice with hindlimb ischemia; KD-H, GABBR2 knockdown (KD) mice with hindlimb ischemia. (B) ATP production changes induced by 6 h of hypoxic treatment in normal and GABBR2-downregulated HUVECs. (C–E) Expression changes of HKII, PFKFB3, and PKM1 induced by 6 h of hypoxic treatment in normal and GABBR2-downregulated HUVECs. *p < 0.05.