TABLE 1.
Data mining (PubChem and ChEMBL): Reported activity of phenazopyridine on targets.
| ChEMBL bioassay Id | Target or Pathway | Species | Concentration |
|---|---|---|---|
| CHEMBL1613769 | Cruzain | Trypanosoma cruzi | 20 µM |
| CHEMBL1794542 | Estrogen receptor alpha signaling | Homo sapiens | 3.1 µM |
| CHEMBL1614421 | Tau Fibril Formation, Thioflavin T Binding | Homo sapiens | 3.9 µM |
| CHEMBL1614240 | Mitochondrial membrane potential | Homo sapiens | 16.7 µM |
| CHEMBL1614204 | Hemoglobin beta chain splicing at IVS2 705 locus | Homo sapiens | 20 µM |
| CHEMBL2114849 | Aryl hydrocarbon receptor (AhR) signaling pathway | Homo sapiens | 39.8 µM |
| CHEMBL2114797 | Rat pregnane X receptor (rPXR) signaling pathway | Rattus norvegicus | 7 µM |
| CHEMBL3215112 | Pregnane X receptor (PXR) signaling pathway | Homo sapiens | 7.9 µM |
| PubChem Bioassay ID | Target name | Species | Concentration |
| 410 | Cytochrome P450 1A2 | Homo sapiens | Na |
| 596 | Microtubule-associated protein tau | Homo sapiens | Na |
| 884 | Cytochrome P450 3A4 isoform 1 | Homo sapiens | 0.1 µM |
| 915 | Hypoxia-inducible factor 1, alpha subunit | Homo sapiens | 0.5 µM |
| 1,851 | Cytochrome P450 1A2 | Homo sapiens | Na |
| 504,332 | Euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens | 10 µM |
| 1,259,343 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | Na |
| 504,749 | Plasmodium falciparum proliferation | Trypanosoma cruzi | Na |