Table 2. Base-Case Cost-effectiveness Results Compared Among Different Strategies by Initial Screening Age Among 100 000 Cohort Members^a.

Initial screening age, strategy	QALYs	Incremental QALYs		Cost ($, thousand)	Incremental cost ($, thousand)		ICER ($/QALY)
		Vs no screening	Vs the next most effective strategyb		Vs no screening	Vs the next most effective strategyb	Vs no screening	Vs the next most effective strategyb
40-44 y
No screening	1 659 260	NA	NA	25 035	NA	NA	NA	NA
Screening once per lifetime	1 660 347	1087	1087	28 334	3299	3299	3035	3035
Screening every 10 y	1 663 677	4417	3330	31 954	6919	3620	1566	1087
Screening every 5 y	1 666 345	7085	2668	36 707	11 672	4753	1647	1781
Screening every 3 y	1 668 371	9111	2026	42 218	17 183	5511	1886	2720
Screening every 2 y	1 669 622	10 362	1251	47 861	22 826	5643	2203	4511
45-49 y
No screening	1 572 532	NA	NA	26 817	NA	NA	NA	NA
Screening once per lifetime	1 574 161	1629	1629	30 347	3530	3530	2167	2167
Screening every 10 y	1 576 941	4409	2780	33 961	7144	3614	1620	1300
Screening every 5 y	1 579 145	6613	2204	37 745	10 928	3784	1653	1717
Screening every 3 y	1 580 974	8442	1829	42 531	15 714	4786	1861	2617
Screening every 2 y	1 582 334	9802	1360	48 190	21 373	5659	2180	4161
50-54 y
No screening	1 468 506	NA	NA	30 229	NA	NA	NA	NA
Screening once per lifetime	1 470 890	2384	2384	34 142	3913	3913	1641	1641
Screening every 10 y	1 472 583	4077	1693	36 373	6144	2231	1507	1318
Screening every 5 y	1 474 773	6267	2190	40 356	10 127	3983	1616	1819
Screening every 3 y	1 476 325	7819	1552	44 120	13 891	3764	1777	2425
Screening every 2 y	1 477 651	9145	1326	49 010	18 781	4890	2054	3688
55-59 y
No screening	1 342 830	NA	NA	36 095	NA	NA	NA	NA
Screening once per lifetime	1 346 031	3201	3201	40 491	4396	4396	1373	1373
Screening every 10 y	1 347 264	4434	1233	42 811	6716	2320	1515	1882
Screening every 5 y	1 348 747	5917	1483	45 240	9145	2429	1546	1638
Screening every 3 y	1 350 365	7535	1618	49 171	13 076	3931	1735	2430
Screening every 2 y	1 351 491	8661	1126	52 843	16 748	3672	1934	3261
60-64 y
No screening	1 195 742	NA	NA	45 876	NA	NA	NA	NA
Screening once per lifetime	1 199 618	3876	3876	51 081	5205	5205	1343	1343
Screening every 5 y	1 201 091	5349	1473	53 970	8094	2889	1513	1961
Screening every 3 y	1 202 293	6551	1202	56 498	10 622	2528	1621	2103
Screening every 2 y	1 203 210	7468	917	58 779	12 903	2281	1728	2487
65-69 y
No screening	1 025 119	NA	NA	60 442	NA	NA	NA	NA
Screening once per lifetime	1 029 058	3939	3939	67 233	6791	6791	1724	1724
Screening every 2 y	1 030 594	5475	1536	70 810	10 368	3577	1894	2329

Abbreviations: ICER, incremental cost-effectiveness ratio; NA, not applicable; QALY, quality-adjusted life-year.

^aQALYs, costs, and ICERs are expressed as the values in 2019.

^bCompared with the next most effective strategy at the same initial screening age.