Figure 1. . Results of mediation analysis of three CpGs associated with macrosomia and GDM at p < 0.05.

All models adjusted for maternal height, age, smoking status, passive smoking exposure, prepregnancy BMI, pregnancy weight gain, parity, pregnancy hypertension, child sex and gestational age at delivery, child age and weight for age z-score at methylation measurement, blood cell type proportions and ten principal components representing processing batch effects (>90% of variance).

GDM: Gestational diabetes mellitus.