Table 1.

Summary of treatment groups for the feasibility of IP4-CHRONOS-A and IP4-CHRONOS-B

Treatment sequence	Number of subjects	Details
IP4-CHRONOS-A
Control arm	Feasibility, N=30	Radical radiotherapy or radical prostatectomy (as per physician and patient decision/preference)
Intervention arm	Feasibility, N=30	Focal therapy using HIFU or cryotherapy (as per physician and patient decision/preference)
Total number	Feasibility, N=60
IP4-CHRONOS-B
Control arm	Feasibility, N=20	Focal therapy using HIFU or cryotherapy (as per physician and patient decision/preference)
Intervention arm 1	Feasibility, N=20	Neoadjuvant finasteride 5mg once daily for a minimum of 12 weeks followed by focal therapy (as per standard care control arm for IP4-CHRONOS-B).
Intervention arm 2	Feasibility, N=20	Bicalutamide 50mg once daily for 12 weeks followed by focal therapy (as per standard care control arm for IP4-CHRONOS-B)
Total number	Feasibility, N=60