Table 2.
Predictors of HCC development.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Gender (male vs. female) | 1.59 (1.08–2.36) | 0.016 | 1.888 (1.267–2.814) | 0.002 |
| Age (per year increase) | 1.06 (1.04–1.08) | <0.001 | 1.054(1.037–1.072) | <0.001 |
| Diabetes (yes vs. no) | 3.03 (1.93–4.76) | <0.001 | 2.235(1.416–3.529) | <0.001 |
| Platelet count (per 109/L) | 0.992 (0.988–0.996) | <0.001 | 0.995(0.991–1.000) | 0.039 |
| ALT (per IU/L) | 0.998 (0.995–1.00) | 0.048 | 0.996(0.991–1.000) | 0.030 |
| AST (per IU/l) | 1.00 (0.997–1.00) | 0.805 | - | - |
| Albumin (per g/L) | 0.943 (0.914–0.974) | <0.001 | 0.998(0.961–1.036) | 0.894 |
| Total bilirubin (per μmol/L) | 1.01 (1.00–1.01) | 0.007 | 1.011(1.004–1.018) | 0.002 |
| HBeAg status (positive vs. negative) | 1.03 (0.731–1.46) | 0.861 | - | - |
| HBV DNA (per log10IU/ml) | 0.971 (0.868–1.09) | 0.606 | - | - |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; HBeAg, hepatitis B e antigen.