Table 4.
Diagnostic accuracy on HCC development in 3 and 5 years by low- and high-risk cut-off of aMAP and other risk scores.
| Risk score | Low-risk groups | High-risk groups | ||||
|---|---|---|---|---|---|---|
| Pts, n (%) | NPV (%) (95% CI) | Pts, n (%) | PPV (%) (95% CI) | |||
| 3 years | 5 years | 3 years | 5 years | |||
| aMAP alone | 143 (13.7) | 98.3 (96.0–100.0) | 96.6 (92.8–100.0) | 393 (37.7) | 12.7 (9.0–16.3) | 25.7 (19.8–31.6) |
| PAGE-B alone | 66 (6.3) | 98.0 (94.1–100.0) | 95.1 (88.2–100.0) | 368 (35.3) | 13.0 (9.2–16.8) | 26.6 (20.5–32.6) |
| mPAGE-B alone | 154 (14.8) | 99.3 (97.9–100.0) | 97.8 (94.6–100.0) | 431 (41.4) | 13.1 (9.5–16.8) | 24.9 (19.4–30.4) |
| CAMD alone | 0 (0) | - | - | 510 (48.9) | 11.9 (8.7–15.1) | 24.8 (19.8–29.9) |
| aMAP and PAGE-B | 61 (5.9) | 97.8 (93.6–100.0) | 94.8 (87.6–100.0) | 294 (28.2) | 12.6 (8.4–16.7) | 26.6 (19.8–33.3) |
| aMAP or PAGE-B | 148 (14.2) | 98.4 (96.1–100.0) | 96.7 (92.9–100.0) | 467 (44.8) | 13.0 (9.6–16.4) | 25.9 (20.5–31.2) |
| aMAP and mPAGE-B | 121 (11.6) | 100.0 (100.0–100.0) | 98.2 (94.7–100.0) | 350 (33.6) | 14.1 (10.0–18.2) | 27.4 (21.0–33.8) |
| aMAP or mPAGE-B | 154 (14.8) | 99.3 (97.9–100.0) | 97.8 (94.6–100.0) | 474 (45.5) | 12.0 (8.8–15.3) | 23.8 (18.6–28.9) |
| aMAP and CAMD | 0 (0) | - | - | 317 (30.4) | 13.5 (9.3–17.6) | 28.1 (21.3–34.9) |
| aMAP or CAMD | 143 (13.7) | 98.3 (96.0–100.0) | 96.6 (92.8–100.0) | 586 (56.2) | 11.6 (8.7–14.5) | 23.6 (19.0–28.2) |
CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.
Low-risk groups include patients with score below the reported low-risk cut-off; high-risk groups include patients with score above the reported high-risk cut-off.