Table 2.
Factors associated with change in disease behavior
| All B1 patients (n = 87) | (L2 + L3) in B1 patients (n = 71) | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | |
| Female | 0.387 | 0.75 (0.39–1.45) | NS | 0.418 | 0.73 (0.35–1.55) | NS | ||
| Smoking | ||||||||
| Former vs. never | 0.974 | NA | NS | 0.984 | NA | NA | ||
| Current vs. never | 0.736 | 1.13 (0.55–2.34) | NS | 0.796 | 0.90 (0.40–2.01) | NS | ||
| Age at diagnosis | ||||||||
| A2 vs. A1 | 0.246 | 2.03 (0.61–6.72) | NS | 0.224 | 2.45 (0.58–10.37) | NS | ||
| A3 vs. A1 | 0.199 | 2.36 (0.64–8.74) | NS | 0.284 | 2.46 (0.47–12.74) | NS | ||
| Location at diagnosis | ||||||||
| L2 vs. L1 | 0.360 | 1.53 (0.61–3.82) | NS | NA | NA | |||
| L3 vs. L1 | 0.931 | 1.04 (0.39–2.80) | NS | NA | NA | |||
| L4 involvement | 0.866 | 1.08 (0.42–2.78) | NS | 0.894 | 0.93 (0.33–2.66) | NS | ||
| Perianal disease | 0.398 | 1.68 (0.51–5.57) | NS | 0.241 | 2.07 (0.62–6.96) | NS | ||
| Appendicectomy | 0.007 | 0.27 (0.11–0.70) | 0.018 | 0.32 (0.12–0.82) | 0.022 | 0.33 (0.13–0.85) | 0.013 | 0.30 (0.11–0.78) |
| Elevated ESR at diagnosis | 0.559 | 1.22 (0.63–2.33) | NS | 0.172 | 1.65 (0.80–3.38) | NS | ||
| CDAI at diagnosis | 0.180 | 1.00 (1.00–1.01) | NS | 0.115 | 1.00 (1.00–1.01) | NS | ||
| 5-Aminosalicylic acid | ≤0.001 | 0.29 (0.15–0.55) | 0.001 | 0.29 (0.14–0.58) | 0.002 | 0.32 (0.16–0.66) | 0.001 | 0.30 (0.14–0.61) |
| Corticosteroid | 0.140 | 0.60 (0.31–1.18) | NS | 0.633 | 0.84 (0.42–1.71) | NS | ||
| Immunomodulators | 0.085 | 0.52 (0.25–1.10) | 0.854 | 0.93 (0.41–2.11) | 0.179 | 0.59 (0.27–1.28) | NS | |
| Biologics | 0.037 | 0.43 (0.20–0.95) | 0.075 | 0.47 (0.21–1.08) | 0.130 | 0.54 (0.24–1.20) | NS | |
HR, hazard ratio; ESR, erythrocyte sedimentation rate; NA, not available; NS, not significance (P > 0.10) in the univariate Cox regression; CDAI: Crohn's disease activity index.