Table 4.
Haplotype frequencies of three PADI2 SNPs in RA and CS.
| Haplotypes | RA n = 229 n (%) | CS n = 333 n (%) | OR (95% CI), p-value |
|---|---|---|---|
| H1: 111 TTT | 229.83 (50.0) | 288.77 (0.43) | 1.32 (1.03-1.67), 0.025 |
| H2: 112 TTC | 5.62 (0.012) | 42.96 (0.064) | 0.18 (0.07-0.43), 0.00002 |
| H3: 121 TCT | 6.72 (0.015) | 36.52 (0.055) | 0.26 (0.11-0.58), 0.0005 |
| H4: 122 TCC | 97.83 (0.21) | 142.74 (0.21) | 0.99 (0.74-1.32), 0.96 |
| H5: 211 GTT | 62.79 (0.13) | 63.11 (0.09) | 1.52 (1.04-2.19), 0.027 |
| H6: 212 GTC | 6.75 (0.01) | 11.16 (0.01) | ND |
| H7: 221 GCT | 7.66 (0.01) | 37.6 (0.05) | 0.28 (0.12-0.62), 0.0008 |
| H8: 222 GCC | 40.79 (0.09) | 43.14 (0.06) | 1.41 (0.90-2.20), 0.13 |
CI, confidence interval; CS, control subjects; H, haplotype; ND, not determinate; OR, odds ratio; RA, rheumatoid arthritis; SNPs, single-nucleotide polymorphisms.
The SNPs are listed in the order: PADI2 rs1005753_T>G, rs2057094_T>C and rs2235926_T>C. The OR and 95% CI and p values were obtained by SHESIS test.
p-value < 0.05 was considered statistically significant.
Bold values represent statistically significant data.