TABLE 2.
Effect1 of selected SNPs2 associated with sample-to-positive (S/P) ratio during the PRRS outbreak for each breed.
SNP name | %TGVM3 | Genotype |
MAF | p-value | ||
AA | AB | BB | ||||
Duroc | ||||||
ASGA0031860 | <0.1 | 1.03 (0.07) | 1.09 (0.04) | 1.04 (0.03) | 0.19 (A) | 0.202 |
MARC0089437 | 9.2 | 0.86b (0.07) | 1.10a (0.05) | 1.21a (0.06) | 0.41 (A) | 0.002 |
ASGA0032063 | <0.1 | 1.04 (0.03) | 1.07 (0.05) | – | 0.05 (B) | 0.519 |
MARC0058875 | 0.2 | 1.04a (0.07) | 0.97b (0.05) | 1.15a (0.06) | 0.41 (B) | 0.018 |
ASGA0032151 | <0.1 | 1.08 (0.06) | 1.06 (0.04) | 1.02 (0.04) | 0.36 (A) | 0.517 |
Landrace | ||||||
ASGA0031860 | <0.1 | 1.51 (0.11) | 1.47 (0.10) | 1.44 (0.10) | 0.35 (A) | 0.511 |
MARC0089437 | <0.1 | – | 1.39a (0.05) | 1.28b (0.02) | 0.04 (A) | 0.034 |
ASGA0032063 | 29.1 | 1.48b (0.12) | 1.55a (0.10) | 1.39c (0.10) | 0.31 (A) | 0.002 |
MARC0058875 | <0.1 | 1.48 (0.10) | 1.45 (0.10) | 1.49 (0.11) | 0.40 (A) | 0.617 |
ASGA0032151 | 0.6 | 1.40b (0.10) | 1.48ab (0.10) | 1.53a (0.10) | 0.41 (B) | 0.054 |
%TGVM, percentage of the total genetic variance of S/P ratio explained by the marker; MAF, minor allele frequency (minor allele in parenthesis); PRRS, porcine reproductive and respiratory syndrome.
1Results for each genotype expressed as expected values for S/P ratio (standard errors within parenthesis), measurement of antibody response to PRRSV.
2SNPs are located on Sus scrofa chromosome 7 as follow according to the Sscrofa11.1 (GCA_000003025.6) assembly: ASGA0031860/rs80959936 (7:22,075,114), MARC0089437/rs80900036 (7:24,217,931), ASGA0032063/rs80940999 (7:24,247,099), MARC0058875/rs80986722 (7:24,865,378), and ASGA0032151/rs80947467 (7:25,967,157). SNP markers MARC0089437 and ASGA0032063 were associated with S/P ratio in this study, in Duroc and Landrace populations, respectively. The other markers were associated with S/P ratio in Landrace sows in Serão et al. (2014).
3The remaining of the TGVM of the S/P ratio QTL after accounting for the %TGVM of these SNPs were 1.5% and <0.1%, for Duroc and Landrace, respectively.
a–cExpected values within row lacking the same superscript indicate differences at p-value <0.05.