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. 2021 Aug 4;12:707873. doi: 10.3389/fgene.2021.707873

TABLE 2.

Effect1 of selected SNPs2 associated with sample-to-positive (S/P) ratio during the PRRS outbreak for each breed.

SNP name %TGVM3 Genotype
MAF p-value
AA AB BB
Duroc
ASGA0031860 <0.1 1.03 (0.07) 1.09 (0.04) 1.04 (0.03) 0.19 (A) 0.202
MARC0089437 9.2 0.86b (0.07) 1.10a (0.05) 1.21a (0.06) 0.41 (A) 0.002
ASGA0032063 <0.1 1.04 (0.03) 1.07 (0.05) 0.05 (B) 0.519
MARC0058875 0.2 1.04a (0.07) 0.97b (0.05) 1.15a (0.06) 0.41 (B) 0.018
ASGA0032151 <0.1 1.08 (0.06) 1.06 (0.04) 1.02 (0.04) 0.36 (A) 0.517
Landrace
ASGA0031860 <0.1 1.51 (0.11) 1.47 (0.10) 1.44 (0.10) 0.35 (A) 0.511
MARC0089437 <0.1 1.39a (0.05) 1.28b (0.02) 0.04 (A) 0.034
ASGA0032063 29.1 1.48b (0.12) 1.55a (0.10) 1.39c (0.10) 0.31 (A) 0.002
MARC0058875 <0.1 1.48 (0.10) 1.45 (0.10) 1.49 (0.11) 0.40 (A) 0.617
ASGA0032151 0.6 1.40b (0.10) 1.48ab (0.10) 1.53a (0.10) 0.41 (B) 0.054

%TGVM, percentage of the total genetic variance of S/P ratio explained by the marker; MAF, minor allele frequency (minor allele in parenthesis); PRRS, porcine reproductive and respiratory syndrome.

1Results for each genotype expressed as expected values for S/P ratio (standard errors within parenthesis), measurement of antibody response to PRRSV.

2SNPs are located on Sus scrofa chromosome 7 as follow according to the Sscrofa11.1 (GCA_000003025.6) assembly: ASGA0031860/rs80959936 (7:22,075,114), MARC0089437/rs80900036 (7:24,217,931), ASGA0032063/rs80940999 (7:24,247,099), MARC0058875/rs80986722 (7:24,865,378), and ASGA0032151/rs80947467 (7:25,967,157). SNP markers MARC0089437 and ASGA0032063 were associated with S/P ratio in this study, in Duroc and Landrace populations, respectively. The other markers were associated with S/P ratio in Landrace sows in Serão et al. (2014).

3The remaining of the TGVM of the S/P ratio QTL after accounting for the %TGVM of these SNPs were 1.5% and <0.1%, for Duroc and Landrace, respectively.

acExpected values within row lacking the same superscript indicate differences at p-value <0.05.