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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Radiol Clin North Am. 2021 Sep;59(5):875–886. doi: 10.1016/j.rcl.2021.05.010

Figure 7.

Figure 7.

Sarcoid-like reaction in a 77-year-old woman with metastatic melanoma treated with pembrolizumab. Oblique MIP (A), CT (B) and fused FDG PET/CT images (C) acquired 13 months after treatment initiation revealed marked FDG uptake in mediastinal and bilateral hilar lymph nodes (arrow) which were new from the prior study and consistent with a sarcoid-like reaction. At the time of the scan there was also a new FDG avid right forearm mass (arrowhead); biopsy of the mass revealed granulomatous inflammation and no tumor. The mass persisted for an additional 12 months (including 5 months of pembrolizumab and 7 months of no therapy) and then spontaneously resolved.