Table 2.
Percentage of Participants Developing Late AMD in 5 Years With Both Eyes Free of Late AMD at Baseline
| No. (%)/Total No. of Participants | |||
|---|---|---|---|
|
| |||
| Scare | ARED5a | AREDS2 | P Value |
|
| |||
| AREDS detailed severity scale score for ail eyes (n = 4302 and 5440 in AREDS and AREDS2, respectively) | |||
|
| |||
| Total | 285/4302 (6.6) | 1232/5440 (22.6) | NA |
|
| |||
| 1, 2, or 3 | 13/2630 (0.5) | 5/206 (2.4) | <.001 |
|
| |||
| 4 | 25/506 (4.9) | 21/323 (6.5) | .34 |
|
| |||
| 5 | 15/268 (5.6) | 47/591 (8.0) | .22 |
|
| |||
| 6 | 50/364 (13.7) | 174/1354 (12.8) | .66 |
|
| |||
| 7 | 97/349 (27.8) | 563/2145 (26.2) | .54 |
|
| |||
| 8 | 63/141 (44.7) | 257/554 (46.4) | .72 |
|
| |||
| 9 (Noncentral GA) | 22/44 (50.0) | 134/219 (61.2) | .17 |
|
| |||
| AREDS simple scale score for all participants (n = 3211 and 2719 in AREDS and AREDS2, respectively) | |||
|
| |||
| Total | 316/3211 (9.8) | 910/2719(33.5) | NA |
|
| |||
| 0 | 6/1466 (0.4) | 0/9 (0) | .85 |
|
| |||
| 1 | 20/635 (3.1) | 5/53 (9.4) | .02 |
|
| |||
| 2 | 55/465 (11.8) | 68/532 (12,8) | .65 |
|
| |||
| 3 | 85/328 (25.9) | 179/681 (26.3) | .90 |
|
| |||
| 4 | 150/317 (47.3) | 658/1444 (45.6) | .57 |
Abbreviations: AMD, age-related macular degeneration; AREDS, Age-Related Eye Disease Study; GA, geographic atrophy; NA, not applicable.
a
Sample size of 4302 includes treated eyes only (excludes placebo).