Table 1.

Inclusion and exclusion criteria in the BCSN trial and CRCbiome study

Inclusion criteria
BCSN	Aged 50–74 years old in 2012
	Resident in selected municipalities in South-East Norway (Østfold, parts of Akershus and parts of Buskerud)
CRCbiome	FIT positive test (i.e. hemoglobin > 15 mcg/g feces) and invited to a follow-up colonoscopy
Exclusion criteria
BCSNa	Death
	Moving out of the area
	Reaching the upper age limit
	Diagnosed with CRC
CRCbiome	Not attending screening colonoscopy
	Low DNA concentration
	Low sequencing yield (< 2 gigabases)

^aExclusion criteria apply for individuals who died, moved out of the area, reached the upper age limit, or were diagnosed with CRC before they were due for invitation