Fig. 4.

Treatment with LPS-EEMos educated for 3 days or 24 h significantly improves survival and clinical scores in mice with lethal ARS when infused 4 h after radiation exposure. On day 0, NSG mice received 4 Gy of lethal radiation followed by an i.v. treatment 4 h later with PBS (vehicle control), 1 × 10⁷ EEMos, or 1 × 10⁷ LPS-EEMos. A Survival curve of treated mice after radiation. B Mean clinical scores (percent weight loss, posture, activity, and fur texture) C Mean percent weight change. D On day 0, NSG mice received 4 Gy of lethal radiation followed by an i.v. treatment 4 h later with PBS (vehicle control), 1 × 10⁷ EEMos, or 1 × 10⁷ LPS-EEMos. Survival curve of treated mice after radiation. E Mean clinical scores. F Mean percent weight change. The final mean percent weight change and clinical score were carried over after death to allow for comparison between groups at a given time point by Kruskal-Wallis with a Dunn post-test. Results pooled from three separate experiments, with 10 to 14 mice/group, for survival analysis. A representative clinical score and weight change from one of 3 experiments are shown, with 2 to 6 mice/group. *p ≤ 0.05, **p ≤ 0.01