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. 2021 Aug 18;16:512. doi: 10.1186/s13018-021-02666-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Downregulation of miR-1-3p expression suppresses chondrocyte hypertrophy and reduces mineralization. A FISH was used to verify miR-1-3p expression in rabbit and human chondrocytes (a). Scale bar: 100 μm. B Introduction of the miR-1-3p inhibitor successfully downregulated miR-1-3p levels in human chondrocytes. C ARS staining of the miR-1-3p-downregulated chondrocytes exhibiting reduced mineralization compared to the controls. Scale bar: 200 μm. D, E Reduced RUNX2 and collagen type X levels in the miR-1-3p-silenced chondrocytes versus the controls. (*P < 0.05, **P < 0.01)