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. 2021 Aug 4;11:652354. doi: 10.3389/fonc.2021.652354

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Copyright © 2021 Zhang, Yuan, Wang, Xu, Cai, Chen and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Differential gene expression analysis of CRC and CLM in CRN.SPARCL1, ORM2, IGFBP1, FGA, APOA2, and VTN were significant differential expressed in CLM. (adjusted p-value < 0.01). (B, C) CDH2 and SPARCL1 were associated with poor prognosis in CRC in DRUGSURV.