Figure 2:

COVID-19 infection associates with reduced plasma C1-inhibitor, alfa2-macroglobulin and increased ITIH4 at first sampling point. Plasma protease inhibitor levels in first samples collected after COVID-19 diagnosis from 27 haemodialysis patients. Seventeen samples were from patients who developed severe disease (red triangles) and 9 samples were from patients with non-severe (blue triangles) COVID-19 only. Samples were collected at median 4 days (IQR: 2–10 days) from positive SARS-CoV2 swab and 6 days (IQR: 4–11 days) from symptom onset. Controls are 32 dialysis patients without COVID-19 (dialysis control cohort, grey squares). Line and whiskers show the mean and standard deviations. Differences in protease inhibitor levels were calculated by one-way ANOVA. All P-values are adjusted with Bonferonni's multiple comparisons tests. ITIH4 was tested in two assays, one measuring intact ITIH4 only and another that in addition also detects any fragmented ITIH4 (total ITIH4).